| Grant Gustin | Barry Allen / The Flash |
| Candice Patton | Iris West-Allen |
| Danielle Panabaker | Caitlin Snow / Killer Frost / Frost |
| Danielle Nicolet | Cecile Horton |
| Kayla Compton | Allegra Garcia |
| Brandon McKnight | Chester P. Runk |
| Jon Cor | Mark Blaine / Chillblaine |
| Avionne Dean | Young Nora |
| Islie Hirvonen | Grace Gibbons |
| Xander Hall | Officer #1 |
| Karin Inghammar | Female Social Worker |
| Jesse Stretch | Truck |
| Klarc Jerome Wilson | Officer Jones |
| Lossen Chambers | Dr. Vanessa Ambres |
| Robert Picardo | Dexter Myles |
| Chris Klein | Orlin Dwyer / Cicada |
| Victoria Park | Kamilla Hwang |
| Patrick Sabongui | David Singh |
| Morena Baccarin | Gideon (voice) (uncredited) |