| Seth MacFarlane | Stan Smith / Roger (voice) |
| Wendy Schaal | Francine Smith (voice) |
| Rachael MacFarlane | Hayley Smith (voice) |
| Scott Grimes | Steve Smith (voice) |
| Dee Bradley Baker | Klaus (voice) |
| Amick Byram | Soup Jingle Singer (voice) |
| Baraka May | Sauce Jingle Singer (voice) |
| Sally Stevens | Sauce Jingle Singer (voice) |
| Diamond White | (voice) |
| Henry Winkler | Child Protection Services Agent (voice) |
| Khary Payton | Prison Guard (voice) |
| Annie Mumolo | Adoptive Mother (voice) |
| Fred Tatasciore | Modeling Advertiser (voice) |
| Fred Savage | Adoptive Father (voice) |
| Ross Marquand | (voice) |
| Eddie Kaye Thomas | Barry Robinson (voice) |
| Nicole Shabtai | Esther Lonstein (voice) |
| Curtis Armstrong | Snot Lonstein (voice) |
| Kevin Michael Richardson | Principal Lewis (voice) |
| Jeff Fischer | Jeff Fischer (voice) |